Publications

2026

Niemeyer CS, Frietze S, Lewis SWR, Artman EC, Coughlan C, Vaseemuddin SI, Nagel MA, Tyring SK, Okundia F, Saviola AJ, Curhan CG, Curhan SG, Restrepo D,  Bubak AN, PHN Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post-Herpetic Neuralgia Patients. 2026 Annals of Neurology. Accepted

Stewart AR, Bustillos Saucedo A, Beauregard L, Link CD, Niemeyer CS, and Rowe RK. HSV-1 Reactivation as an Emergent Property of Neuronal Stress: Implications for Traumatic Brain Injury. 2026 Journal of Neuroinflammation. PMID: 42387516

Niemeyer CS, Nagel MA, Restrepo D, Bubak AN. HSV-1 and VZV co-reactivation: Implications for worsening neurological and neurodegenerative diseases. 2026. Journal of NeuroVirology. PMID: 42418127

Frietze S, Lunn C, Boyd J, Oldham D, Bubak AN, Bustillos A, Bruce KD, Niemeyer CS. Intranasal HSV-1 Infection polarizes microglia towards interferon signaling and away from Homeostasis. 2026. PLOS Pathogens, Under Review. PMID: 41928984

Lucero MJ, Lisk C, Swindle D, Cendali F, Setua S, Thangaraju K, Khan A, Pak DI, O’Boyle Q, Lu S, Tolson R, Zaeske S, Khan S, Rana N, Westover N, DavizonCastillio P, George G, Hassell K, Nuss R, Brinkman N, Gentinetta T, Niemeyer CS, Cabrales P, Palmer A, D’Alessandro A, Buehler PW, Irwin DC. Combined haptoglobin and hemopexin therapy for the treatment of cardiopulmonary dysfunction in sickle cell disease. Biomedicine & Pharmacotherapy 2025 PMID: 40997624

Niemeyer CS, Merle L, Bubak AN, Dnate’ Baxter, Gentile Polese A, Colon-Reyes K, Vang S, Hassell Jr.JE, Nagel MA, Restrepo D. Olfactory and Trigeminal Routes of HSV-1 CNS infection with Regional Microglial  Heterogeneity. J Virol. 2024. PMID: 39475273

Niemeyer CS, Frietze S, Coughlan C, Lewis SWR, Bustos Lopez S,  Saviola AJ, Hansen KC, Medina, EM, Hassell JE Jr,  Kogut S, Traina-Dorge V,  Nagel MA,  Bruce KD, Restrepo D, Mahalingam R, BubaK AN, Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. J Virol. 2024 Jul 25:e0084824.PMID: 39051773

Niemeyer CS, Harlander-Locke M, Bubak AN, Rzasa-Lynn R, Birlea M. Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment. Curr Pain Headache Rep. 2024 Apr;28(4):295-306. doi: 10.1007/s11916-023-01209-z. Epub 2024 Jan 23. PMID: 38261232; PMCID: PMC10940365.

Cleland NR, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Research. 2024 Apr 15;1829:148772.

Niemeyer CS, Traina-Dorge V, Doyle-Meyers L, Das A, Looper J, Mescher T, Feia B, Medina E, Nagel MA, Mahalingam R, Bubak AN. Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid. J Neurovirol. 2024 Feb;30(1):86-99. doi: 10.1007/s13365-024-01196-w.

Nagel MA, Gershon AA, Mahalingam R, Niemeyer CS, Bubak, A.N. Varicella vaccines. In: Plotkin’s Vaccines, 8th Edition (Orenstein W, Offit P, Edwards KM, Plotkin S, eds.), Elsevier Publishing. Chap. 63:1215-1250.e17, 2023. 

Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA. Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk. J Infect Dis. 2023 Apr 18;227(8):993-1001. doi: 10.1093/infdis/jiac405.

 Bubak, A.N., Como, C.N., Hassell, J.E. Jr., Mescher, T., Frietze, S.E., Niemeyer, C.S., Cohrs, R.J., Nagel, M.A.: Targeted RNA sequencing of VZV-infected brain vascular adventitial fibroblasts indicates that amyloid may be involved in VZV vasculopathy. Neurol. Neuroimmunol. Neuroinflamm. 9:e1103; doi: 10.1212/NXI.0000000000001103, 2022.

 Niemeyer, C.S., Mescher, T., Bubak, A.N., Medina, E.M., Hassell, J.E. Jr., Nagel, M.A.: VZV infection of primary human adrenal cortical cells produces a proinflammatory environment without cell death. Viruses 14:674; doi: 10.3390/v14040674, 2022.

 Mahalingam, R., Feia, B., Coleman, C., Anupindi, K., Saravanan, P., Luthens, A., Bustilios, A., Das, A., de Haro, E., Doyle-Meyers, L., Looper, J., Bubak, A.N., Niemeyer, C.S., Palmer, B., Nagel, M.A., Traina-Dorge, V.: Simian varicella virus pathogenesis in skin during varicella and zoster. Viruses 14:1167; doi: 10.3390/v14061167, 2022.

 Bubak, A.N., Coughlan, C., Posey, J., Saviola, A.J., Niemeyer,C.S., Lewis, S.W.R., Bustos Lopez, S., Solano, A., Tyring, S.K., Delaney, C., Neeves, K.B., Mahalingam, R., Hansen, K.C., Nagel, M.A.: Zoster-associated prothrombotic plasma exosomes and increased stroke risk. J. Infect. Dis. jiac405; doi: 10.1093/infdis/jiac405, 2022.

 Bubak, A.N., Merle, L, Niemeyer, C.S., Baxter, B.D., Polese, A.G., Ramakrishnan, V., Gomez, J., Madrigal, L., Villegas-Lanau, A., Lopera, F., Macklin, W., Frietze, S., Nagel, M.A., Restrepo, D.: Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer’s disease. Neurobiol. Aging 123:75-82, 2022.

Baxter, B.D., Larson, E.D., Merle, L., Feinstein, P., Polese, A.G., Bubak, A.N., Niemeyer, C.S., Hassell, J. Jr., Shepherd, D., Ramakrishnan, V.R., Nagel, M.A., Restrepo, D.: Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium. BMC Genomics 22;224, 2021.

 Niemeyer, C.S., Mescher, T., Griggs, R., Orlicky, D.J., Wilkerson, G.K., Bubak, A.N., Hassell, J.E. Jr., Feia, B., Mahalingam, R., Traina-Dorge, V., Nagel, M.A.: Histopathological analysis of adrenal glands after simian varicella virus infection. Viruses 13:1245; doi: 10.3390/v13071245, 2021.

 Bubak, A.N., Mescher, T., Mariani, M., Frietze, S.E., Hassell, J.E. Jr., Niemeyer, C.S., Como, C.N., Burnet, A.M., Subramnian, P.S., Cohrs, R.J., Mahalingam, R., Nagel, M.A.: Targeted RNA sequencing of formalin-fixed, paraffin-embedded temporal arteries from giant cell arteritis cases reveals viral signatures. Neurol. Neuroimmunol. Neuroinflamm. 8:e1078; doi: 10.1212/NXI.0000000000001078, 2021.

Bubak, A.N., Como, C.N., Coughlan, C.M., Johnson, N.R., Hassell, J.E. Jr., Mescher, T., Niemeyer, C.S., Mahalingam, R., Cohrs, R.J., Boyd, T.D., Potter, H., Russ, H.A., Nagel, M.A.: Varicella-zoster virus infection of primary human spinal astrocytes produces intracellular amylin, amyloid-β, and an amyloidogenic extracellular environment. J. Infect. Dis. 221:1088-1097, 2020.

Nagel, M.A., Niemeyer, C.S., Bubak, A.N.: Central nervous system infections produced by varicella zoster virus. Curr. Opin. Infect. Dis. 33:273-278, 2020.

 Hudish. L., Bubak, A.N., Triolo, T., Niemeyer, C.S., Sussel, L., Nagel, M.A., Taliaferro, M.J., Russ, H.A.: Modeling hypoxia induced neuropathies using a fast and scalable human motor neuron differentiation system. Stem Cell Reports 14:1033-1043, 2020.